Table 4.
The change in human renal hemodynamics after long-term treatment for essential hypertension using diuretics.
| Diuretics | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug | References | RBF/RPF | Pglom | GFR | FF | RVR | Duration (weeks) | Participant number |
| Hydrochlorothiazide | Van Brummelen et al., 1979 | = | = | = |  |
36 | 10 (males) | |
| O'Connor et al., 1981;Warren et al., 1981 | = | = | = | |
4 | 19 (males) | ||
| Scaglione et al., 1992 | = | = | = | |
8 | 13 | ||
| Chlorothiazide | Loon et al., 1989 | = | = | = | 4 | 9 | ||
| Furosemide | Olshan et al., 1981;Warren et al., 1981 | = | = | = | =† | 4 | 12 | |
| Spironolactone | Falch et al., 1979a | = | 12 | 10 | ||||
| Matthesen et al., 2013 | = | 4 | 23 | |||||
| Furosemide and spironolactone | Loon et al., 1989 | = | = | = | 4 | 6 | ||
| Amiloride | Matthesen et al., 2013 | = | 4 | 23 | ||||
| Indapamide | Pickkers et al., 1998 | |
|
= | 6 | 11 | ||
RBF/RPF, renal blood flow/renal plasma flow; GFR, glomerular filtration rate; FF, filtration fraction; RVR, renal vascular resistance; , significant decrease from control; 
, significant increase from control; =, no significant change from control.
†
An apparently anomalous result, given that for individual subjects RVR = MAP/RBF, MAP falls significantly, and yet neither RBF nor RVR are found to change significantly; the discrepancy arises from the statistical distribution within the study group.