Skip to main content
. 2016 Jul 29;7:317. doi: 10.3389/fphys.2016.00317

Figure 1.

Figure 1

Influenza A M2 protein. (A) The domain organization of full-length M2 encompasses the transmembrane domain (TMD) comprised of residues 25–46 shown in green. (B) The structure of M2TMD tetramer reported by X-ray crystallography (PDB 3C9J): The TM helices are further away at the C-terminus; Amantadine (in red) is bound to the central pore of M2TMD channel. The Cβ-atoms of residue L46, which was substituted for cysteine in this work, are depicted as blue spheres. The lipid bilayer was added for clarity. (C) M2TMD21−49 peptides (wt and G34A mutant) used in this work: The residues corresponding to the TMD are in green, whereas the N- and C-terminal juxtamembrane residues are in black. In the second peptide, the alanine residue at position 34 is in red. The L46C residue used for spin-labeling is in enlarged font. (D) The amantadine hydrochloride molecule.