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EM micrographs of M2TMD21−49 nanogold labeled at position L46C and reconstituted into DOPC/POPS membranes. The data shown in (A,B) are those without and with 2 mM amantadine, respectively. In both cases the P/L was 1:10,000. The blue boxes are the areas contained inside green circles magnified by a factor of 20 to emphasize monomers, dimers and tetramers of M2TMD21−49.
