Table 3.

A. fumigatus CYP51A mutations detected directly from respiratory samples.

Specimen	Patient category	Clinical diagnosis	Culture/azole susceptibility	Mutations*	Prior azole therapy dosage and duration
Sputum	SOT	Colonization	A. fumigatus/ITC = 16 mg/L, POS =1 mg/L, VRC = 4 mg/L	TR34/L98H	POS 800 mg/d for 1 year
BAL	SOT	Colonization	Negative	I217T	No
BA	HAEM	Colonization	Negative	R355H	No
BA	HAEM	Colonization	Negative	L399F	No
Sputum	CF	ABPA	A. fumigatus/susceptible	I354V	No
BA	PULM	CPA	A. fumigatus/susceptible	promoter -129 T to C	VRC 400 mg/d for 3 months until 3 months before sampling
BAL	HAEM	IA	Negative	D70D; T140T	No
BA	HAEM	IA	Negative	L77L	No
BA	PULM	ABPA	Negative	R65R	No
BAL	SOT	Control	Negative	E356E	VRC 400 mg/d for 2 years

ITC, itraconazole; POS, posaconazole; VRC, voriconazole.

^*Non-synonymous mutations are bolded.