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. 2016 Jun 20;78:313–323. doi: 10.1007/s00280-016-3077-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Combination activity for AZD1775 and SN-38. a FA and b CI values of AZD1775 and SN-38 assessed at 25 different concentrations. c Isobologram analysis of the combination demonstrating synergy at ED90 with 3 different drug ratios. d Single and combination drug–response curves for the combination showing cytotoxicity of the drug combination compared to single agent. e CI–FA plot showing synergy in all 4 RMS cells lines across a broad arrange of FA values in this drug combination