Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Aug 29;53:4728–4744. doi: 10.1007/s12035-015-9399-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 4 — Immunohistochemical analyses of young and old tg-aSYN-B6, tg-aSYN-mtNOD and C56BL/6 control mice (Ctrl). Semi-quantitative analysis of immunolabelling reveals significant differences in neuron integrity between young and old mice and especially between old tg-aSYN-B6 and old control mice (a). Examination of microglial response shows a significant difference between 300-day-old tg-aSYN-mtNOD and 300-day-old control mice (b). Young tg-aSYN-B6 (c) and tg-aSYN-mtNOD (e) mice show a more intensive NeuN-staining as compared with old mice (d and g); old tg-aSYN-B6 mice also reveal less neurons in cortical layer V. There are hardly any changes visible in the GFAP labelling (o–t), whereas Iba1 labelling shows slightly stronger microglial activity in old transgenic mice (j, l) compared with C57BL/6J control mice (n). Scale bar = 100 μm in c–t. Data is presented as means ± SD (n ≥ 5), *p ≤ 0.05; **p ≤ 0.01; ***p < 0.001 (one-way ANOVA followed by Sidak’s multiple comparison test)