Table 3.
Parameter estimates of the final model in adult cancer patients
| Parameter | Estimate | Shrinkage (%) | Bootstrap | |
|---|---|---|---|---|
| Median | 95 % CI | |||
| CL (mL/h) | 8.6 | 8.6 | [8.37, 8.82] | |
| V1 (mL) | 2678 | 2678 | [2616, 2736] | |
| Q (mL/h) | 18.6 | 18.7 | [16.6, 21.3] | |
| V2 (mL) | 2423 | 2417 | [2291, 2568] | |
| BWT on CL and Qa | 0.589 | 0.586 | [0.501, 0.666] | |
| Male on CLb | 1.14 | 1.15 | [1.11, 1.19] | |
| ALBU on CLa | −0.473 | −0.474 | [− 0.619, −0.323] | |
| Missing ALBU on CL | 41.8 g/L | |||
| BALP on CLa | 0.312 | 0.321 | [0.132, 0.526] | |
| Missing BALP on CL | 76.3 U/L | |||
| IFNa on CLa | 0.844 | 0.843 | [0.780, 0.905] | |
| BWT on V1 and V2a | 0.470 | 0.469 | [0.396, 0.541] | |
| Male on V1b | 1.18 | 1.18 | [1.13, 1.22] | |
| Prop. error (%) | 21.8 | 12.0 | 21.7 | [20.7, 22.9] |
| Add. error (μg/mL) | 0.0553 | 12.0 | 0.0553 | [0.0438, 0.0678] |
| IIV CL (%) | 29.2 | 17.7 | 29 | [27.2, 31.0] |
| IIV V1 (%) | 18.3 | 44.3 | 18.2 | [15.6, 20.9] |
| IIV V2 (%) | 41.4 | 43.8 | 41.8 | [33.2, 49.3] |
Add. additive, ALBU baseline albumin, BALP alkaline phosphatase, CI confidence interval, CL clearance (mL/h), IIV inter-individual variability, IFNa interferon alpha treatment, Prop. proportional, Q inter-compartment clearance, V1 central volume of distribution, V2 peripheral volume of distribution
aValue of the exponent θ eff estimated in the model
bValues calculated as “eθeff,” where θ eff is the value of covariate effect for male estimated with the model