Table 1.
Composition of beads
| Batch code | Sodium alginate (% w/v) | Calcium chloride (% w/v) | Sodium carboxymethyl cellulose (% w/v) | Acacia (%w/v) | HPMC K4M (% w/v) |
HPMC K15M (% w/v) |
Cellulose acetate phthalate (% w/v) |
|---|---|---|---|---|---|---|---|
| Formulations with alginate alone | |||||||
| F1 | 0.4 | 2 | – | – | – | – | – |
| F2 | 1 | 2 | – | – | – | – | – |
| F3 | 1 | 1 | – | – | – | – | – |
| F4 | 0.5 | 0.4 | – | – | – | – | – |
| Uncoated formulations with alginate and polymer blends | |||||||
| F5 | 1.25 | 3.75 | 4.25 | – | – | – | – |
| F6 | 1.25 | 3.75 | – | 2.5 | – | – | – |
| F7 | 1.25 | 3.75 | – | – | 1.875 | – | – |
| F8 | 1.25 | 3.75 | – | – | – | 1.25 | – |
| Coated formulations with alginate and polymer blends | |||||||
| F9 | 1.25 | 3.75 | 4.25 | – | – | – | 5 |
| F10 | 1.25 | 3.75 | – | 2.5 | – | – | 5 |
| F11 | 1.25 | 3.75 | – | – | 1.875 | – | 5 |
| F12 | 1.25 | 3.75 | – | – | – | 1.25 | 5 |
Each formulation contains 2 mg of ceftriaxone sodium. Blank (without drug) formulations were also prepared for formulations F1–F12