Table 1. Change in ALT and AST levels after probiotic therapy.
| Months of therapy | No. of subjects |
Mean ALT ± SD (IU/L) |
p value | Mean AST ± SD (IU/L) |
p value |
|---|---|---|---|---|---|
| Initial | 39 | 64.8 ± 17.5 | 64.3 ± 28.7 | ||
| 3 M | 39 | 34.9 ± 15.1 | 0.000 | 63.2 ± 33.7 | NS |
| 6 M | 37 | 27.9 ± 13.0 | 0.000 | 51.6 ± 29.2 | NS |
| 9 M | 36 | 31.6 ± 21.1 | 0.000 | 46.2 ± 21.7 | 0.006 |
| 12 M | 35 | 27.1 ± 14.5 | 0.000 | 46.6 ± 17.9 | 0.002 |
| 15 M | 33 | 36.5 ± 27.8 | 0.000 | 47.1 ± 21.8 | 0.008 |
| 18 M | 31 | 32.7 ± 21.2 | 0.000 | 42.7 ± 20.1 | 0.000 |
| 21 M | 31 | 40.0 ± 43.0 | 0.002 | 43.5 ± 22.5 | 0.002 |
| 24 M | 31 | 42.9 ± 31.3 | 0.000 | 53.5 ± 47.0 | NS |
| 27 M | 28 | 32.0 ± 23.2 | 0.000 | 46.1 ± 31.9 | 0.012 |
| 30 M | 24 | 39.3 ± 21.3 | 0.009 | 44.5 ± 20.6 | 0.009 |
| 33 M | 24 | 56.0 ± 39.1 | NS | 59.4 ± 39.8 | NS |
| 36 M | 23 | 43.7 ± 25.2 | 0.003 | 60.1 ± 43.4 | NS |
NS: not significant.