Table 1.
Characteristics of the study subjects
| All subjects (n = 79) | AD (n = 25) | MCI (n = 19) | Control (n = 16) | p value | |
|---|---|---|---|---|---|
| Female/male | 43/36 | 18/7 | 7/12 | 9/7 | |
| Age, years | 70.5 (7.5) | 70.9 (7.3) | 76.0 (7.3) | 70.1 (6.7) | n.s. |
| CSF Aβ1–42, pg/ml | 628 (254) | 478 (142) | 658 (309) | 779 (187) | n.s. |
| CSF tau, pg/ml | 416 (293) | 601 (338) | 457 (334) | 245 (96) | n.s. |
| CSF p-tau, pg/ml | 74 (34) | 97 (37) | 76 (35) | 56 (20) | n.s. |
| MMSE (0–30) | 23.5 (4.4) | 21 (3.5) | 24.4 (3.2) | 26.2 (5.1) | 0.039* |
| Verbal Fluency (0–24) | 14.0 (5.5) | 13.3 (5.1) | 14.7 (4.5) | 18.1 (3.8) | 0.020* |
| Word List Delayed Recall, n (%) | 61 (32) | 49 (30) | 60 (29) | 85 (25) | 0.002** |
| Constructional Praxis Recall, n (%) | 64 (33) | 45 (28) | 66 (30) | 85 (29) | 0.029* |
| CERAD Total Scorea (0–111) | 66 (16) | 59 (12) | 67 (16) | 78 (15) | 0.045* |
| Memory Total Scoreb (0–41) | 26.5 (6.3) | 22.6 (4.6) | 26.8 (6.0) | 31.7 (6.4) | 0.014* |
| Learning Efficiencyc (1–10) | 1.7 (0.7) | 1.5 (0.5) | 2.0 (1.0) | 1.7 (0.5) | n.s. |
| Executive Function Scored (1–30) | 20.0 (6.9) | 19.2 (6.8) | 21.0 (5.5) | 24.7 (5.3) | n.s. |
Data are numbers of cases or means (SD), unless otherwise indicated. p values are given for the differences between AD, MCI and control groups. n.s. = Not significant; MMSE = Mini-Mental State Examination.
a
According to Seo et al. [13].
b
According to Paajanen et al. [12].
c
Word List Memory (3rd trial – 1st trial).
d
CERAD Word List Learning Efficiency Score (0–10) + Verbal Fluency (0–24) + Clock-Drawing test score.
*
p ≤ 0.05.
**
p ≤ 0.005.