Table 2.
The relationship between CSF biomarkers and the CERAD-NB subtests and compound scores in the different diagnostic groups
| Group | Variable | Women | Men | Both sexes | Correlation with CSF biomarkers |
| All | Verbal Fluency (0–24) | 14.6 (5.0) | 13.3 (5.9) | 14.0 (5.5) | n.s. |
| patients | Word List Delayed Recall | 3.6 (2.1) | 3.7 (2.4) | 3.7 (2.2) | women: p = 0.035 (Aβ1–42), p = 0.050* (tau), p = 0.046 (p-tau) all: p = 0.048 (Aβ1–42) |
| Word List Delayed Recall, n (%) | 59.3 (28.1) | 62.1 (36.6) | 60.6 (32.0) | n.s. | |
| Constructional Praxis Recall, n (%) | 60.9 (32.9) | 67.0 (33.6) | 63.6 (33.1) | women: p = 0.049 (Aβ1–42) | |
| all: p = 0.026 (Aβ1–42), p = 0.047* (tau) | |||||
| CERAD Total Scorea (0–111) | 65.1 (14.2) | 66.4 (18.9) | 65.7 (16.3) | women: p = 0.008 (Aβ1–42) | |
| Word List Learning Efficiencyb (1–10) | 1.7 (0.8) | 1.7 (0.7) | 1.7 (0.7) | n.s. | |
| AD | Verbal Fluency (0–24) | 14.8 (4.5) | 9.43 (4.6) | 13.3 (5.1) | n.s. |
| Word List Delayed Recall | 2.7 (1.7) | 2.6 (2.6) | 2.7 (1.9) | n.s. | |
| Word List Delayed Recall, n (%) | 49.0 (26.3) | 49.0 (41.57) | 49.0 (30.3) | n.s. | |
| Constructional Praxis Recall, n (%) | 46.9 (23.8) | 37.5 (43.3) | 44.7 (28.2) | n.s. | |
| CERAD Total Scorea (0–111) | 62.8 (9.8) | 44.8 (8.8) | 58.8 (12.1) | all: p = 0.030 (tau), p = 0.046 (p-tau) | |
| Word List Learning Efficiencyb (1–10) | 1.5 (0.5) | 1.6 (0.7) | 1.5 (0.5) | n.s. | |
| MCI | Verbal Fluency (0–24) | 13.7 (3.4) | 15.3 (5.1) | 14.7 (4.5) | n.s. |
| Word List Delayed Recall | 2.6 (1.9) | 4.5 (1.8) | 3.8 (2.0) | all: p = 0.017 (Aβ4–42) | |
| Word List Delayed Recall, n (%) | 45.6 (29.2) | 68.6 (27.2) | 60.1 (29.4) | men: p = 0.002 (Aβ1–42) | |
| all: p = 0.003 (Aβ1–42) | |||||
| Constructional Praxis Recall, n (%) | 62.3 (36.8) | 67.4 (27.4) | 65.5 (30.1) | n.s. | |
| CERAD Total Scorea (0–111) | 58.4 (13.6) | 71.6 (15.5) | 67.2 (15.7) | n.s. | |
| Word List Learning Efficiencyb (1–10) | 2.2 (1.4) | 1.9 (0.8) | 2.0 (1.0) | men: p = 0.018 (Aβ1–42) all: p = 0.036 (Aβ1–42) | |
| Control | Verbal Fluency (0–24) | 17.3 (4.8) | 19.0 (1.7) | 18.1 (3.8) | n.s. |
| Word List Delayed Recall | 5.4 (2.5) | 6.0 (1.3) | 5.7 (2.1) | n.s. | |
| Word List Delayed Recall, n (%) | 77.2 (30.1) | 97.6 (5.8) | 85.4 (25.3) | n.s. | |
| Constructional Praxis Recall, n (%) | 76.7 (35.7) | 96.1 (10.3) | 85.2 (28.7) | all: p = 0.033 (Aβ1–42) | |
| CERAD Total Scorea (0–111) | 74.6 (18.1) | 81.8 (9.1) | 77.5 (15.2) | n.s. | |
| Word List Learning Efficiencyb (1–10) | 1.6 (0.3) | 1.8 (0.6) | 1.7 (0.5) | n.s. | |
Data are means (SD), unless otherwise indicated. The values marked in bold are the ones showing a significant correlation with one or more CSF biomarkers. The significant p values are given in the right column, separately for the different study groups.
Values missing from statistical analyses: Verbal Fluency: 1 AD woman, 1 frontotemporal dementia (FTD) man; Word List Delayed Recall: 1 control man; Constructional Praxis Recall: 5 AD women, 3 FTD women, 1 MCI woman, 1 other woman, 3 MCI men, 3 AD men, 3 other (depression, stroke/alcohol) men; CERAD Total Score: 4 AD women, 4 FTD women, 2 MCI women, 1 other woman, 3 AD men, 2 MCI men, 1 control man, 1 FTD man, 1 Parkinson's disease dementia man, 1 depression man, 1 other man; CSF tau: 1 MCI woman, 1 MCI man; CSF p-tau: 3 MCI women, 2 AD women, 1 control woman, 2 MCI men, 1 AD man, 1 depressed man; both CSF tau and CERAD Total Score: 1 MCI woman; both CSF p-tau and Constructional Praxis Recall and CERAD total score: 1 AD man, 1 depressed man. n.s. = Not significant.
According to Seo et al. [13]
Word List Memory (3rd trial – 1st trial).