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. 2016 Jun 1;291(31):15923–15939. doi: 10.1074/jbc.M115.709493

FIGURE 6.

FIGURE 6.

BPA neurotoxicity mediated via enhanced Drp-1 mitochondrial translocation in the hippocampus and hippocampal NSC-derived neurons. a, BPA treatment increased Drp-1 mitochondrial translocation in hippocampal (dentate gyrus) neurons of the rat brain as evident from increased co-localization of Drp-1 with mitochondrial protein TOMM20. BPA exposure both during PNDs 21 and 90 enhanced the co-localization of Drp-1 and TOMM20 (mitochondrial protein) in the hippocampus region. Arrows show Drp-1/TOMM20 co-labeled cells. The values are means ± S.E. (n = 6 rats/group). *, p < 0.05 versus control. Scale bar, 100 μm. b, Drp-1 silencing and NAC inhibited BPA-induced Drp-1 mitochondrial translocation as evident from reduced co-localization of Drp-1 with mitochondrial protein TOMM20 in the hippocampal NSC-derived neurons in culture. The values are means ± S.E. (n = 3 independent experiments). *, p < 0.05 versus control. Scale bar, 20 μm.