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The degradation of HBV-RNA by the SKIV2L/RNA exosome pathway. A ribosome may skip the first HBV X ORF translation site and instead initiate translation from the 3′ precore start codon. Due to the lack of an in-frame stop codon, such a ribosome will stall in the poly(A) tail of the transcript. The stalled ribosome will be recognized by HBS1L, which in turn will induce NSD RNA quality control, leading to the degradation of the HBV X-mRNA by the SKIV2L-RNA exosome system.
