FIGURE 6.

Modeling the structure of the Tn complex. A–C, sequence alignments used in modeling the three TnC, TnH/TnI, and TnT chains. For TnT, the sequence alignment results in three major insertions (C). D, structural alignment obtained on the model resulting from our iterative procedure. The helical regions are now aligned, and the gaps are grouped in the loop between the helices and at the N terminus. For each alignment, the template sequences of the human complex (1YTZ and 1J1D) are shown at the top, with the Lethocerus sequence at the bottom.