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. 2016 Jun 7;291(31):16282–16291. doi: 10.1074/jbc.M116.737593

TABLE 1.

Predictions from in silico analysis of AIPL1 mutants investigated in this study

PolyPhen SIFT PMut Chaperone activity
R38C Probably damaging Damaging Pathological Yes
R53W Probably damaging Damaging Pathological Yes
V71F Probably damaging Damaging Pathological No
W72S Probably damaging Damaging Pathological No
C89R Probably damaging Damaging Pathological No
V96I Benign Tolerated Neutral Yes
T114I Benign Tolerated Pathological Yes
Y134F Possibly damaging Tolerated Neutral Yes
C239R Probably damaging Damaging Pathological No
G262S Possibly damaging Tolerated Neutral Yes