Table 3. Prognostic factors in cutaneous T cell lymphoma cases.

Clinical factors Age 5, 8, 52, 77 Sex 52 Staging 47, 52, 53 Extent and type of cutaneous involvement 1, 9, 47, 53 Presence of extracutaneous involvement 1, 5, 46, 52 such as blood 1, 5, 52, 53, bone marrow 8, and adnexal 9 involvement Disease progression 1 Old refractoriness to successive treatment protocols 5

Laboratory factors Proliferation index 52 Folliculotropism 52 Presence of Sézary cells 5, 40 Large cell transformation in histology 14, 41, 52 White blood cell/lymphocyte count 52 Loss of T cell receptor repertoire 39 Increased level of soluble interleukin-2 receptor at initial diagnosis 9 Normal or high levels of lactate dehydrogenase 8, 52, 77 CD30 expression of less than 10% 52, 77 Overexpression of TOX 22 Expression of proliferation markers Ki-67, MCM-3, and MCM-7 78 MicroRNA profiling 25 Granulysin expression 27 Presence of FOXP3 + regulatory T cells 27 EPHA4 expression 13