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. 2016 Jul 29;6:30436. doi: 10.1038/srep30436

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Copyright © 2016, The Author(s)

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(a) Mitochondrial respiration reflected by OCR levels was detected in wild-type (WT), cell overexpressing 26- (internal control) and 78-CAG repeats (MJD78) in ATXN3 gene with or with FIR treatment under basal conditions or following the addition of oligomycin (O, 1 μM), the uncoupler FCCP (F, 0.5 μM) or the electron transport inhibitor Rotenone (R, 2 μM) (n = 5). (b) The rates of basal respiration, (c) ATP-linked respiration, (d) maximal respiratory capacity was quantified by normalization of OCR level to the total protein OD values. *p < 0.05, compare to WT group; ⁺p < 0.05, compare to non-treated MJD26 group; ^#p < 0.05, compare to each non-treated group of MJD cells.