Figure 4. rhES-AuNPs-PEG improves vascular integrity and reduces leakage.

(a) CD31 staining of tumour sections. Scale bars: 100 μm. (b) FITC-dextran and CD31 staining of leakage in tumours. The ratio of the FITC-stained area to CD31⁺ area was determined and is presented as the relative value (***P < 0.001; **P < 0.01). Scale bars: 200 μm. (c) Endothelial cells and pericytes were visualized by CD31 (red) and α-SMA (green) staining of tumours (**P < 0.01). Scale bars: 200 μm.