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. 2016 Jul 29;6:30467. doi: 10.1038/srep30467

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Copyright © 2016, The Author(s)

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Overall synaptic density (approximated using PSD-95) in the molecular layer surrounding the DG was not affected by NRG1 administration (A), and this was also the case in analyzing particular zones adjacent to various aspects of the DG (B), although there was heterogeneity in synapse-related immunoreactivity between these zones. (C) dendritic synapse-related labeling by DCX (green) and PSD-95 (red) staining in BrdU-identified immature neurons. (D) Dendritic synapse-related puncta density was unaffected by NRG1 administration. (E) somatic synaptic labeling by DCX (green) and PSD-95 (red) staining in BrdU-identified immature neurons. Somatic synapse-related puncta density was unaffected by NRG1 administration (F). Scale bar = 10 μm. **p ≤ 0.01; ****p ≤ 0.0001. SAL, saline.