Table 1. Specificity of effects of neuregulin-1 on adult hippocampal neurogenesis.
| STAGE | OVERALL | DORSAL | VENTRAL |
|---|---|---|---|
| PROLIFERATION | ↑ | X | ↑ |
| DIFFERENTIATION | X | X | X |
| SURVIVAL | X | X | X |
| CELL BODY MORPHOLOGY | X | X | X |
| DENDRITIC MORPHOLOGY | X | X | X |
| SYNAPSE DEVELOPMENT | X | X | X |
| OVERALL NEUROGENESIS | ↑ | X | ↑ |
Neuregulin-1 has temporally and subregionally specific neurogenic effects, wherein cell proliferation and overall neurogenesis are increased selectively in the ventral dentate gyrus following administration, and other neurogenic features (including neuronal differentiation, cell survival, cell body and dendritic morphology, and synapse formation) in immature neurons are unaffected. Proliferation, differentiation, and overall neurogenesis were assessed in ref. 12.