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. 2016 Jul 29;6:30846. doi: 10.1038/srep30846

Figure 5. Pharmacological inhibition of c-Myc and PDK reduces glycolysis-derived lactate production in JFH-1 infected Huh7.5 cells.

Figure 5

(a) Extracellular acidification rates (ECAR) in JFH-1-infected Huh 7.5 cells treated with JQ1 (500 nM) for 72 hr. *P < 0.001 compared with uninfected control cells; **P < 0.001 compared with HCV infection alone. Glc, Glucose; Oligo, oligomycin; 2DG, 2-deoxyglucose. (b) ECAR in JFH-1-infected Huh 7.5 cells treated with DCA (10 mM) for 72 hr. *P < 0.001 compared with uninfected control cells; **P < 0.001 compared with HCV infection alone. (c) Lactate levels in JFH-1-infected Huh 7.5 cells treated with JQ1 (500 nM) for 72 hr. *P < 0.001 compared with uninfected control cells; **P < 0.001 compared with HCV infection alone. (d) Lactate levels in JFH-1-infected Huh7.5 cells treated with DCA (10 mM) for 72 hr. *P < 0.001 compared with uninfected control cells; **P < 0.001 compared with HCV infection alone.