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. 2016 Jul 29;6:30659. doi: 10.1038/srep30659

Figure 5. Pretreatment with SFN prevents depression after repeated social defeat stress.

Figure 5

(a) The schedule of treatment and behavioral evaluations. (b) Social interaction test (SIT): no target, (c) SIT: target. (d) 1% sucrose preference test (SPT), (e) total fluid intake test (FIT) for SPT. Data represent the mean ± S.E.M. (n = 10–14). *P < 0.05, ***P < 0.001 compared with the vehicle-treated stress group (two-way ANOVA). (f,g) Western blot of Keap1, Nrf2 in the mouse brain regions. Data represent the mean ± S.E.M. (n = 5 or 6). *P < 0.01, **P < 0.01, ***P < 0.001 compared with the vehicle-treated stressed group (two-way ANOVA). (h,i) Western blot of BDNF, p-TrkB/TrkB in the mouse brain regions. Data represent the mean ± S.E.M. (n = 5 or 6). *P < 0.01, **P < 0.01, ***P < 0.001 compared with the vehicle-treated stress group (two-way ANOVA).