Figure 3. The involvement of the Ly49E receptor in cutaneous B16F10-induced tumour development.

(A) WT mice were inoculated subcutaneously with the indicated number of B16F10 melanoma cells (5 mice with 10⁴ cells, 10 mice with 2000 cells and 10 mice with 400 cells) and tumour development was monitored. (B) Age- and sex-matched WT (■) (n = 40) and Ly49E KO mice (□) (n = 40) were injected subcutaneously with 1500 B16F10 melanoma cells and tumour growth was analysed. The percentage of tumour onset is shown in (B), the percentage of mice bearing tumours larger than 1 cm² is shown in (C). The data shown are representative of two independent experiments. (B,C) Datasets were statistically analysed using the Log-rank Kaplan-Meier method. There were no significant differences in WT versus Ly49E KO mice.