Table 3. Top 10 enriched proteins identified in CR compared to CN ascites tumor cells.
| Protein Accession | Gene symbol | Protein Description | CN | CR | RSC | Gene ontology (GO) |
|---|---|---|---|---|---|---|
| Q99715 | COL12A1 | Collagen alpha-1 (XII) chain | 1 | 23 | 12.1 | cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development |
| P08243 | ASNS | Asparagine synthetase [glutamine-hydrolyzing] | 1 | 20 | 10.6 | ATP binding; L-asparagine biosynthetic process; activation of signaling protein activity involved in unfolded protein response; asparagine biosynthetic process; asparagine synthase (glutamine-hydrolyzing) activity; cellular protein metabolic process; cellular response to glucose starvation; cellular response to hormone stimulus; cofactor binding; cytosol; glutamine metabolic process; liver development; negative regulation of apoptotic process; positive regulation of mitotic cell cycle; response to amino acid; response to follicle-stimulating hormone; response to light stimulus; response to mechanical stimulus; response to methotrexate; response to toxic substance |
| P37268 | FDFT1 | Squalene synthase (Farnesyl-diphosphate farnesyltransferase) | 1 | 12 | 6.6 | cellular lipid metabolic process; cholesterol biosynthetic process; endoplasmic reticulum membrane; farnesyl diphosphate metabolic process; farnesyl-diphosphate farnesyltransferase activity; integral component of membrane; isoprenoid biosynthetic process; oxidoreductase activity; squalene synthase activity |
| O60701 | UGDH | UDP-glucose 6-dehydrogenase | 3 | 23 | 6.4 | NAD binding; UDP-glucose 6-dehydrogenase activity; UDP-glucose metabolic process; UDP-glucuronate biosynthetic process; cellular glucuronidation; cytosol; electron carrier activity; gastrulation with mouth forming second; glycosaminoglycan biosynthetic process; xenobiotic metabolic process |
| Q96C36 | PYCR2 | Pyrroline-5-carboxylate reductase 2 | 4 | 26 | 5.8 | L-proline biosynthetic process; cytoplasm; pyrroline-5-carboxylate reductase activity |
| Q9UKF6 | CPSF3 | Cleavage and polyadenylation specificity factor subunit 3 | 1 | 10 | 5.6 | 5′-3′ exonuclease activity; RNA binding; endoribonuclease activity; histone mRNA 3’-end processing; mRNA cleavage; mRNA cleavage and polyadenylation specificity factor complex; mRNA export from nucleus; mRNA polyadenylation; mRNA splicing, via spliceosome; metal ion binding; ribonucleoprotein complex; termination of RNA polymerase II transcription |
| B4DHQ3 | PSAT | Phosphoserine aminotransferase | 1 | 10 | 5.6 | L-serine biosynthetic process; O-phospho-L-serine:2-oxoglutarate aminotransferase activity; pyridoxal phosphate binding |
| Q8NFF5 | FLAD1 | FAD synthase | 3 | 19 | 5.3 | ATP binding; FAD biosynthetic process; FMN adenylyltransferase activity; Mo-molybdopterin cofactor biosynthetic process; cytosol; mitochondrial matrix; riboflavin metabolic process |
| O15230 | LAMA5 | Laminin subunit alpha-5 | 1 | 9 | 5.1 | angiogenesis; cell migration; cell proliferation; cell recognition; cilium assembly; cytoskeleton organization; embryo development; endothelial cell differentiation; establishment of protein localization to plasma membrane; extracellular matrix organization; extracellular space; focal adhesion assembly; integrin binding; integrin-mediated signaling pathway; laminin-1 complex; laminin-10 complex; laminin-11 complex; laminin-5 complex; lung development; morphogenesis of a polarized epithelium; morphogenesis of embryonic epithelium; muscle organ development; neural crest cell migration; odontogenesis of dentin-containing tooth; regulation of cell adhesion; regulation of cell migration; regulation of cell proliferation; regulation of embryonic development; structural molecule activity; substrate adhesion-dependent cell spreading |
| Q6UX53 | METTL7B | Methyltransferase-like protein 7B | 1 | 9 | 5.1 | methyltransferase activity |
Rsc: Spectral count ratio (CR/CN).