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Mean (± SEM) number of infusions earned in the HiS and LoS female and male groups. Filled symbols refer to HiS and open symbols refer to LoS groups. Circles indicate females and triangles indicate males. Overall, HiS rats earned more infusions than LoS rats (* p < 0.05) and females earned more cocaine infusions than males and HiS rats earned more infusions than LoS rats (# p < 0.05). There were significant dose-dependent decreases in the number of infusions earned.
