Osswald et al.3
report that, in some types of brain tumour, structures called microtubes connect
tumour cells, allowing them to act as a single, organism-like unit. Tumour
microtubes facilitate invasion into healthy brain tissue. They permit the spread
of toxic molecules such as calcium ions (Ca2+) that build up
during radiation therapy, allowing the whole unit to share the burden of
toxicity. Furthermore, if tumour tissue is surgically removed, newly synthesized
nuclei donated by tumour cells can travel down the microtube to the cell-free
site to form new tumour cells.