Table 1.

Comparison of different prognostic parameters with survival in 30 uveal melanoma patients

		Univariate analysis—unknown cases attributed to death due to other causes
			95% confidence interval
Parameters	n	HR	Lower	Upper	p Value
Standard clinical/histological parameters
Gender
Male	17	–	–	–	–
Female	13	1.3	0.5	3.7	0.63
Ciliary body involvement
No	17	–	–	–	–
Yes	13	6.3	1.9	21.0	0.002
Stage group
I and IIA	9	–	–	–	–
IIB	10	5.0	0.6	45.0	0.14
IIIA	9	16.9	2.1	138.8	0.009
IIIB	2	5.8	0.4	92.6	0.22
Age at enucleation (years; low to high; continuous)	30	1.0	1.0	1.1	0.26
Largest basal diameter (mm; low to high; continuous)	30	1.4	1.1	1.7	0.008
Chromosomal aberrations
FISH on isolated nuclei, cut-off at 5%
Disomy chromosome 3	11	–	–	–	–
Monosomy chromosome 3	19	12.1	1.6	93.2	0.017
FISH on isolated nuclei, cut-off at 30%
Disomy chromosome 3	15	–	–	–	–
Monosomy chromosome 3	15	11.6	2.5	52.5	0.002
SNP on tumour DNA
Disomy chromosome 3	14	–	–	–	–
Monosomy chromosome 3	16	20.3	2.6	156.7	0.004
Disomy chromosome 8q	11	–	–	–	–
Gain chromosome 8q	19	11.7	1.5	89.7	0.018
Disomy chrom 3+disomy chrom 8q	10	–	–	–	–
Monosomy chrom 3+gain chrom 8q	15	8.9	2.0	40.4	0.004
Gene expression
15-gene expression assay class
Class 1	14	–	–	–	–
Class 2	14	8.5	1.9	38.3	0.005
BAP1 gene expression (dichotomised at median)
High	14	–	–	–	–
Low	14	8.7	1.9	39.7	0.006
BAP1 gene expression (high to low; continuous)	28	4.0	1.5	10.6	0.006
Immunohistochemistry
Positive BAP1 immunostaining	14	–	–	–	–
Negative BAP1 immunostaining	14	5.5	1.5	20.1	0.010

An univariate Cox regression analysis was performed.

FISH, fluorescence in situ hybridization; SNP, single nucleotide polymorphism.