Table 2.

Cox Proportional Hazards Analysis of Clinical, Pathologic, and Molecular Prognostic Variables

Covariate	Regression Coefficient, β (SE)	Wald Statistic	P Value	Hazard Coefficient, Exp(b) (95% CI)
Ciliary body involvement^a	−0.391 (0.391)	1.002	.32	0.68 (0.32–1.45)
Epithelioid cells^a	−0.020 (0.369)	0.003	.96	0.98 (0.48–2.01)
Class 2 GEP^a	2.335 (0.449)	26.949	<.001	10.33 (4.30–24.84)
Patient age^a	0.013 (0.0119)	1.154	.28	1.01 (0.99–1.04)
Tumor thickness^a	0.043 (0.0516)	0.709	.40	1.04 (0.95–1.16)
LBD^a	0.125 (0.056)	5.049	.02	1.13 (1.02–1.26)
Class 1 GEP^b	0.151 (0.083)	3.272	.07	1.16 (0.99–1.37)
Class 2 GEP^b	0.126 (0.045)	7.789	.005	1.13 (1.04–1.24)

Abbreviations: GEP, gene expression profile; LBD, largest basal tumor diameter.²

Expressed as results of multivariate Cox proportional hazards regression, performed on 339 patients with uveal melanoma, with progression-free survival as the end point.

Expressed as results of univariate Cox proportional hazards regression, performed on 190 patients with class 1 and 149 patients with class 2 uveal melanoma, with LBD as the variable and progression-free survival as the end point.