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. 2016 Jan 27;19(7):pyw007. doi: 10.1093/ijnp/pyw007

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© The Author 2016. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Behavioral abnormalities in polyriboinosinic-polyribocytidilic acid [poly(I:C)] offspring. Effects of poly(I:C) on startle reflex (A-C) and prepulse inhibition (PPI) (D) parameters. Graphs show that offspring from poly(I:C)-treated mothers exhibited impairments in PPI but not in startle indices. Values are expressed as mean±SEM. ***P<.001 vs rats treated with vehicle (main effect of treatment). Prepulses are indicated by the intensity corresponding to decibels above background noise. AU, arbitrary units; %IBR, percent inter-block ratio; ms, milliseconds. For further details, see text. (E) Graphs show that offspring of poly(I:C)-treated mothers exhibited reduced discrimination index toward a novel object and (F) reduced social interactions. Data are expressed as means±SEM. *P<.01 vs rats treated with vehicle (CTRL group).