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. 2016 Jan 27;19(7):pyw007. doi: 10.1093/ijnp/pyw007

Figure 3.

Figure 3.

Enhanced extracellular dopamine (DA) levels in the nucleus accumbens (NAc) shell of polyriboinosinic-polyribocytidilic acid [poly(I:C)]-treated rats and effects of quinpirole and cocaine. Extracellular dopamine concentrations in the NAc shell (A) and medial prefrontal cortex (mPFC) (B) of control (CTRL) and poly(I:C) rats. (C) These graphs show the effect of systemically administered quinpirole (QUIN, 0.2mg/kg, s.c., n=5–6) on extracellular dopamine levels in the NAc shell expressed as percent of baseline (left) or in absolute values (pg/sample, right). (D) Locally perfused cocaine (COC, 100 µM, n=9–12) enhances extracellular dopamine levels in the NAc shell. Data are expressed as percent of baseline (left) or in absolute values (pg/sample, right). The arrow represents the time of quinpirole administration, whereas the solid line represents the time of cocaine perfusion. Values are the mean±SEM and are expressed as pg/20 µL dialysate. *P<.05, unpaired t test with Welch’s correction.