Figure 1.

Central injection of a GPR120 agonist acutely inhibits food intake. (A) Cumulative food intake following acute central agonist injection. GPR120 agonist treatment elicited up to an 80% and 72% reduction in food intake at the first and second hour postinjection, respectively (n=11). (B) A selective GPR40 agonist (1 μM) did not influence food intake (n=9). (C) A single ICV injection of the GPR120 agonist had no overall effect on locomotor activity; however, it produced a trend (P=.1) for increased ambulatory activity during the first hour postinjection (n=5/group). Mean ± SEM; *P<.05, *** P<.001.