Table 2.
Cardiovascular and Hormone Data from Group-2
| Cardiovascular | PL | SA | KET | KETSA | F(3,33) | P |
Pairwise Comparisons (Bonferroni) P value |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PL:SA | PL:KET | PL:KETSA | SA:KET | SA:KETSA | |||||||
| SBP_pk (mm Hg) | -2.50 (5.00) | 12.00 (10.14) | -0.75 (3.82) | 6.92 (13.38) | 8.13 | .003 | .013 | NS | NS | .011 | NS |
| SBP_AUC (mm Hg·min) | -236.88 (288.58) | 222.92 (504.39) | -98.75 (259.67) | -281.88 (496.15) | 4.59 | .012 | NS | NS | NS | NS | .070 |
| DBP_pk (mm Hg) | -2.00 (4.20) | 9.00 (7.48) | -5.00 (7.19) | 1.67 (8.49) | 12.25 | <.001 | .004 | NS | NS | .001 | .062 |
| DBP_AUC (mm Hg·min) | -247.71 (266.43) | 153.75 (280.70) | -277.08 (357.59) | -165.83 (281.18) | 5.58 | .007 | .058 | NS | NS | .008 | .039 |
| HR_pk (bpm) | -0.75 (5.99) | 6.75 (10.01) | -0.92 (4.62) | 2.83 (10.88) | 2.71 | .083 | NS | NS | NS | NS | NS |
| HR_AUC (bpm·min) | -162.08 (277.20) | -31.67 (268.53) | -223.33 (383.41) | -371.88 (437.46) | 2.03 | .144 | NS | NS | NS | NS | NS |
| Hormones | |||||||||||
| Cort_pk (μg/dL) | -0.66 (5.62) | 6.06 (7.44) | -3.74 (5.61) | 4.75 (6.43) | 7.44 | .004 | .009 | NS | .081 | .083 | NS |
| Cort_AUC (μg/dL·min) | -269.1 (600.9) | 425.0 (691.3) | -750.0 (569.8) | 83.7 (562.5) | 11.98 | .001 | .005 | NS | NS | .013 | .078 |
| GH_pk (ng/mL) | 1.60 (1.66) | 4.71 (3.80) | 1.83 (2.77) | 3.67 (3.23) | 3.55 | .032 | NS | NS | NS | NS | NS |
| GH_AUC (ng/mL·min) | 162.2 (213.2) | 304.9 (278.4) | 135.4 (184.7) | 206.9 (225.3) | 1.51 | .233 | NS | NS | NS | NS | NS |
| Prol_pk (ng/mL) | 0.78 (4.45) | 20.78 (14.81) | 1.48 (5.69) | 28.18 (18.10) | 20.79 | <.001 | .007 | NS | .002 | .012 | NS |
| Prol_AUC (ng/mL·min) | -26.2 (547.5) | 1231.1 (903.8) | 182.8 (776.4) | 1698.9 (1216.4) | 18.48 | <.001 | .002 | NS | .001 | .034 | NS |
Abbreviations: AUC, area under the curve; Cort, cortisol; DBP, diastolic blood pressure; GH, growth hormone; HR, heart rate; KET, ketanserin+placebo; KETSA, ketanserin+salvinorinA; pk, peak value; PL, placebo+placebo; Prol, prolactin; SA, placebo+salvinorin-A; SBP, systolic blood pressure.
Effects induced by placebo (placebo+placebo), salvinorin-A (placebo+salvinorin-A), ketanserin (ketanserin+placebo), and ketanserin+salvinorin-A on cardiovascular and neuroendocrine measures. Means (SD) of values obtained (n=12), and results of the statistical analyses performed. The comparison ketanserin vs ketanserin+salvinorin-A has been omitted.