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. 2016 Jun 27;126(8):2821–2826. doi: 10.1172/JCI84705

Figure 1. Pilus-1 promotes invasion of S. pneumoniae into the brain.

Figure 1

C57BL/6 mice were infected i.v. with (A) serotype 6B isolates, (B) TIGR4 and isogenic pilus mutants, and (C) D39 and piliated D39▼(rlrA-srtD). Graphs show the number of pneumococci found in the brain: each dot represents 1 mouse; black bars show the average values. n = 15 per group (3 experiments with n = 5 per group). *P < 0.05, **P < 0.01, and ***P < 0.001, by nonparametric ANOVA, followed by Dunn’s test (A and B) and by nonparametric, 2-tailed Wilcoxon’s rank-sum test (C).