Skip to main content
. 2016 Jun 27;126(8):2821–2826. doi: 10.1172/JCI84705

Figure 2. Pneumococci carrying pilus-1 invade the brain as single cocci.

Figure 2

(A) Immunofluorescence staining of the polysaccharide capsule of 6B clinical isolates, TIGR4, and TIGR4ΔrrgA-srtD from brain and lung homogenates and blood and (B) D39, D39▼(rlrA-srtD), TIGR4ΔrrgBC, and TIGR4ΔrrgA from brain homogenates and blood. A mixed phenotype was found for BHN427 (A), and in the brain, among piliated strains, only a minor part formed diplococci (see detailed quantification in the Supplemental Information). For each strain and each type of tissue, 3 mice were analyzed (approximately 300 images per mouse were taken).