Figure 5. Irf3^–/– mice exhibit reduced adipose and systemic inflammation.

Male WT and Irf3^–/– mice were fed HFD for 16 weeks, n = 7–8 per genotype. (A and B) Gene expression of IRF3 target genes in eWAT (A) and iWAT (B) of Irf3^–/– mice on HFD. (C) Plasma cytokine levels in Irf3^–/– mice on HFD. Data are presented as mean ± SEM. For all data, *P < 0.05.