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. 2016 Jul 11;126(8):2839–2854. doi: 10.1172/JCI86080

Figure 7. Irf3–/– mice show improved insulin sensitivity on HFD.

Figure 7

(A) Fed and fasting plasma insulin levels in WT and Irf3–/– mice on 16 weeks of HFD (n = 7–8 per genotype). (B) Glucose tolerance test after 8 weeks on HFD. (C) Insulin tolerance test after 10 weeks on HFD. (D) Insulin-stimulated Akt and p70S6K phosphorylation in iWAT of WT and Irf3–/– mice after 16 weeks on HFD. (E) Quantification of Western blot in D. (F) Glucose tolerance testing of WT and Irf3–/– mice after 6 weeks of HFD, prior to weight divergence. (G) Insulin tolerance testing of WT and Irf3–/– mice after 8 weeks of HFD, prior to weight divergence. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 for all panels.