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. 2016 Jul 25;126(8):2941–2954. doi: 10.1172/JCI87715

Figure 2. Met treatment improves decidual health.

Figure 2

(A) Met reduced the number of γH2AX-positive cells in p53d/d deciduae. Scale bar: 250 μm. (B) Met attenuated decidual senescence in p53d/d females. Scale bar: 500 μm. (C) Met upregulated Prlr expression in p53d/d deciduae. Scale bar: 500 μm. (D) pAMPK localization is low in p53d/d deciduae and increased after Met treatment. Scale bar: 250 μm. bv, blood vessel; Dec, decidua; Lb, labyrinth; Sp, spongiotrophoblast. (E and F) pAMPK, pRAPTOR, and pS6 expression and quantitation in day 16 deciduae. pAMPK and pRAPTOR levels were lower in p53d/d females with increased pS6 levels. Scale bar: 500 μm. *P < 0.05, mean ± SEM, Student’s t test.