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. 2016 Jul 25;126(8):2941–2954. doi: 10.1172/JCI87715

Figure 3. Met and Rsv regulate COX2-derived PG synthesis.

Figure 3

(A) Upregulated Cox2 in p53d/d deciduae was inhibited by Met. Dec, decidua; Lb, labyrinth; Sp, spongiotrophoblast. Scale bar: 500 μm. (B and C) Decidual PG levels on day 17 after Met treatment. PGF2α levels were higher in p53d/d than in p53fl/fl mice after LPS injection, and levels were suppressed by combined treatment with Met and P4 (n = 6, *P < 0.05, mean ± SEM, Student’s t test). (D) PG levels in decidualized stromal cells after treatment with Met or Rsv. Met reduced PGF2α levels in both p53fl/fl and p53d/d decidualized stromal cells, while Rsv had little effect. Met or Rsv inhibited PGE2 levels in p53fl/fl and p53d/d decidualized stromal cells (n = 6, *P < 0.05, mean ± SEM, Student’s t test). (E and F) Met and Rsv attenuated Ptgs2 (encoding COX2) mRNA levels in decidualized mouse stromal cells (n = 3, *P < 0.05, mean ± SEM, Student’s t test).