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. 2016 Jul 25;126(8):2941–2954. doi: 10.1172/JCI87715

Figure 5. p53 inversely regulates pAMPK and mTORC1 signaling.

Figure 5

(A and B) Met or rapamycin (Rapa) inhibited pS6 in decidualized mouse stromal cells; Met alone stimulated pAMPK signaling. (C–F) Met (10 mM) or Rsv (50 μM) treatment of p53fl/fl and p53d/d decidualized mouse stromal cells increased pAMPK levels in p53d/d decidual cells with concomitant decreased pS6 levels. (G and H) pS6 levels significantly increased in p53–/– MEFs compared with control cells. pAMPK and pS6 levels in WT and p53–/– MEFs were inversely regulated by Met. *P < 0.05, mean ± SEM, ANOVA.