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. 2016 Jul 25;126(8):2941–2954. doi: 10.1172/JCI87715

Figure 7. p53 induces SESN2 expression to modulate AMPK and mTORC1 signaling.

Figure 7

(A–E) Nutlin and Doxo upregulated the levels of p53, SESN2, and pAMPK with downregulation of pS6 levels in decidualized stromal cells (n = 3, *P < 0.05, mean ± SEM, ANOVA). (F–I) SESN2 overexpression inversely regulated pAMPK and pS6 levels (n = 3, *P < 0.05, mean ± SEM, Student’s t test).