Figure 9. A schematic representation of the role of decidual p53-sestrin interactions to integrate AMPK and mTORC1 signaling in determining parturition timing.

Increased AMPK signaling by SESNs in mouse and human decidual cells with downregulation of mTORC1 signaling by p53 and further enhanced by Met or Rsv provides protection against preterm birth (PTB) This downregulation of mTORC1 signaling with increased pAMPK activity is reflected in attenuated protein translation involving pS6K and/or p4EBP1. This perhaps helps rescue PTB.