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Apparent KD of canakinumab for human and marmoset IL-1β
| kon [105/Ms] | koff [10−5/s] | KD [pM] | ||
|---|---|---|---|---|
| Human IL-1β | 11.0 ± 0.24 | 3.30 ± 0.29 | 30.5 ± 2.6 | n=22 |
| Marmoset IL-1β | 15.4 ± 0.37 | 3.46 ± 0.35 | 22.8 ± 2.5 | n=20 |
Association (kon) and dissociation (koff) rate constants and equilibrium binding constant (KD) were determined by surface plasmon resonance. Values represent mean ± SD (standard deviation), n denotes the number of independent evaluations.
