Table 2.
Cox Proportional Hazards Regression Analysis: Association Between Duration of ADT and Each Psychiatric End Point
| Factor | Depression | Outpatient Psychiatric Treatment | Inpatient Psychiatric Treatment | ||||||
|---|---|---|---|---|---|---|---|---|---|
| AHR* | 95% CI | P | AHR* | 95% CI | P | AHR* | 95% CI | P | |
| Months of ADT | |||||||||
| None | Ref | Ref | Ref | ||||||
| 1-6 | 1.12 | 1.03 to 1.21 | .008 | 0.97 | 0.87 to 1.10 | .66 | 1.16 | 1.02 to 1.32 | .02 |
| 7-11 | 1.26 | 1.15 to 1.39 | < .001 | 1.03 | 0.90 to 1.19 | .65 | 1.28 | 1.10 to 1.50 | .002 |
| ≥12 | 1.37 | 1.26 to 1.49 | < .001 | 1.20 | 1.07 to 1.35 | .002 | 1.47 | 1.29 to 1.68 | < .001 |
| P trend | 1.11 | 1.08 to 1.14 | < .001 | 1.06 | 1.02 to 1.10 | .004 | 1.14 | 1.09 to 1.19 | < .001 |
| Age at diagnosis | 1.04 | 1.03 to 1.04 | < .001 | 1.05 | 1.04 to 1.06 | < .001 | 1.04 | 1.03 to 1.05 | < .001 |
| Race | |||||||||
| Black v white | 0.74 | 0.66 to 0.82 | < .001 | 1.11 | 0.96 to 1.27 | .15 | 0.58 | 0.48 to 0.70 | < .001 |
| Other v white | 0.71 | 0.61 to 0.82 | < .001 | 0.65 | 0.52 to 0.82 | < .001 | 0.64 | 0.49 to 0.82 | < .001 |
| Unmarried v married | 1.23 | 1.15 to 1.32 | < .001 | 1.44 | 1.30 to 1.58 | < .001 | 1.37 | 1.23 to 1.53 | < .001 |
| CCI | |||||||||
| 1 v 0 | 1.23 | 1.15 to 1.32 | < .001 | 1.22 | 1.11 to 1.35 | < .001 | 1.32 | 1.18 to 1.47 | < .001 |
| ≥ 2 v 0 | 1.92 | 1.77 to 2.09 | < .001 | 2.01 | 1.79 to 2.25 | < .001 | 2.36 | 2.08 to 2.68 | < .001 |
| Risk group | |||||||||
| B v A | 1.09 | 1.02 to 1.17 | .009 | 1.14 | 1.04 to 1.25 | .007 | 1.04 | 0.93 to 1.15 | .52 |
| C v A | 1.08 | 0.96 to 1.20 | .20 | 1.07 | 0.91 to 1.26 | .40 | 1.00 | 0.83 to 1.20 | .97 |
Abbreviations: ADT, androgen deprivation therapy; AHR, adjusted hazard ratio; CCI, Charlson comorbidity index; Ref, reference.
*
Additional adjustments included education level, income, population density, year of diagnosis, primary treatment with radiation therapy, and primary treatment with radical prostatectomy.