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. 2015 Sep 4;7(6):1084–1093. doi: 10.1080/19420862.2015.1075109

Figure 2.

Figure 2.

CDR charge balancing improves the cynomolgus monkey pharmacokinetics of mAbs. Pharmacokinetic profiles of (A) mAbs A and B and (B) C and D. mAbs A and C are CDR charge balanced from mAbs B and D, respectively. Data are the mean of 2 animals/time point for mAb D. Data are the mean ± SD (standard deviation) for 4 animals/time point for mAb C and 3 animals/time point for mAbs A and B. The pharmacokinetics were assessed following a single IV dose of 2 mg/kg for mAbs A and B and 10 mg/kg for mAb C and D.