Table 1.

General description of the IgGs^*

Compounds	mAb Isotype	CDR Charge Patch Engineered	Increased FcRn Affinity	TMD In Cynomolgus Monkeys
A	IgG1	+	−	−
A-V308P	IgG1	+	+	−
B	IgG1	−	−	−
B-V308P	IgG1	−	+	−
C	IgG4	+	−	+
C-V308P	IgG4	+	+	+
D	IgG4	−	−	+
D-V308P	IgG4	−	+	+

^*All the molecules are humanized IgGs. The ‘+’ and ‘−’ signs indicate the presence and absence of a characteristic, respectively.