Table 2.

Biophysical and cynomolgus monkey FcRn binding properties of the IgGs

				Tm (°C)
Compounds	Cynomolgus Monkey FcRn Kd (nM) at pH 6	Heparin Binding at 100 μg/mL (OD450-OD630)	pI	CH2	CH3	Fab
A	105 ± 5	0.034 ± 0.0019	8.8	67	83	70
A-V308P	2.3 ± 0.2	0.039 ± 0.0012	8.6	68	83	72
B	115 ± 3	0.134 ± 0.0061	9.1	71	83	72
B-V308P	2.1 ± 0.6	0.116 ± 0.0015	9.0	70	82	70
C	93 ± 4	0.410 ± 0.0151	9.2	69	72	76
C-V308P	1.6 ± 0.8	0.426 ± 0.0016	9.1	71	72	74
D	121 ± 15	3.899 ± 0.0018	9.5	69	73	76
D-V308P	0.9 ± 0.2	3.961 ± 0.0015	9.5	71	70	78