Table 3.
Cynomolgus monkey pharmacokinetic parameters of the IgGs
| Antibodies | Dose (mg/kg) | Cmax (μg/mL) | AUC0-inf (hr*μg/mL) | CL (mL/hr/kg) | T1/2 (hr) |
|---|---|---|---|---|---|
| A | 2 (n = 3) | 32 + 3 | 4091 + 929 | 0.51 + 0.12 | 397 + 213 |
| A-V308P | 2 (n = 3) | 38 + 3 | 10583 + 1880 | 0.19 + 0.03 | 443 + 18 |
| B | 2 (n = 3) | 17 + 8 | 1148 + 339 | 1.87 + 0.67 | 145 + 33 |
| B-V308P | 2 (n = 3) | 10 + 2 | 2864 +238 | 1.02 + 0.58 | 431 + 241 |
| C | 10 (n = 4) | 226 + 22 | 5431 + 747 | 1.86 + 0.28 | 132 + 44 |
| C-V308P | 10 (n = 3) | 245 + 27 | 6762 + 1151 | 1.51 + 0.26 | 77 + 34 |
| D | 10 (n = 2) | 114 | 1059 | 9.70 | 161 |
| D-V308P | 10 (n = 3) | 119 + 23 | 1437 + 178 | 7.02 + 0.82 | 132 + 78 |
Cmax, maximal observed serum concentration; AUC0-inf, area under the serum concentration curve from time zero extrapolated to infinite time; CL, clearance; T1/2, elimination half-life.