Table 3.
Patents with Freeman et al as inventors outlicensed by Harvard and Dana-Farber to BMS, Merck, Roche, Novartis, Boehringer Ingelheim, Amplimmune, and MerckSerono
| Patent | Title | Inventors | priority date | Assignee | claimed subject matter |
|---|---|---|---|---|---|
| US7638492 | PD-1, a receptor for B7-4, and uses therefor | Wood + Freeman | Aug 23, 1999 | NIH | immune stimulation by administration of a dysfunctional B7-4 |
| US7635757 | B7-4 polypeptides and uses therefor | Freeman, Boussiotis, Chernova + Malenkovich | Aug 23, 1999 | NIH | antibody against B7-4 |
| US7101550 | PD-1, a receptor for B7-4, and uses therefor | Wood + Freeman | Aug 23, 1999 | NIH | Immune stimulation by administration of an antibody against B7-4 |
| US7038013 | Novel B7-4 molecules and uses therefor | Freeman, Boussiotis, Chernova + Malenkovich | Aug 23, 1999 | Dana Farber | Sequence of B7-4 |
| US6936704 | Nucleic acids encoding costimulatory molecule B7-4 | Freeman, Boussiotis, Chernova + Malenkovich | Aug 23, 1999 | NIH | encoding sequence for B7-4 |
| US6808710 | Downmodulating an immune response with multivalent antibodies to PD-1 | Wood + Freeman | Aug 23, 1999 | Dana Farber+ NIH | immune downmodulation by administration of an anti PD-1 antibody |
| US7709214 | PD-L2 Molecules: Novel PD-1 Ligands and Uses Therefor | Freeman, Chernova, Malenkovich + Wood | June 28, 2000 | Dana Farber + Wyeth | immune stimulation by adminstration of an anti-PD-L2 antibody or a dysfunctional PD-L2 |
| US7432059 | PD-L2 molecules: novel PD-1 ligands and uses therefor | Freeman, Chernova, Malenkovich, Wood, Latchman + Sharpe | June 28, 2000 | Dana Farber+ NIH | screening method |
| US7700301 | PD-1, a receptor for B7-4, and uses therefor | Wood, Freeman + Chaudhary | April 02, 2001 | NIH | screening method |
| US8652465 | Methods and compositions for the treatment of persistent infections | Freeman, Sharpe, Dorfman, Ahmed, Barber + Wherry | June 08, 2005 | Dana Farber; Emory; Harvard College; NIH | method of reducing viral titer by adminstration of an anti PD-L1 antibody |
| US8552154 | HUMAN ANTI-PD-1, PD-L1, AND PD-L2 ANTIBODIES AND USES THEREFOR | Freeman, Ahmed, Jones, Carr + Gregson | Sept 26, 2008 | Dana Farber + Emory | antibody (sequence specified) against PD-L1 |