Table 3.
Antibody isotype, viscosity and SCM scores for MedImmune antibodies. IgG1κ-YTE has triple mutations in the Fc domain for higher FcRn binding19
mAb | Isotype | Viscosity [mPa-s] | SCM score |
---|---|---|---|
M1 | IgG1κ | 11.1 | 876 |
M2 | IgG1κ | 25.8 | 2223 |
M3 | IgG1κ | 5.4 | 980 |
M4 | IgG1κ-YTE | 14.3 | 1724 |
M5 | IgG1κ | 14.9 | 1724 |
M6 | IgG1κ | 13.2 | 1589 |