Skip to main content
. 2016 Jul 22;9:4505–4516. doi: 10.2147/OTT.S100037

Figure 4.

Figure 4

MiR-490-3p targets RhoA and influences RhoA downstream factors directly in vitro.

Notes: (A) The predicted seed region in the 3′ UTR of RhoA proved that RhoA is a direct target of miR-490-3p. (B) Dual-luciferase reporter assay showing that miR-490-3p targeted RhoA directly by binding its 3′ UTR. (C) MiR-490-3p overexpression reduced RhoA, Bcl-xL, MMP-9, and P70S6K protein expression. Each result represents the mean of three independent experiments. *P<0.05.

Abbreviations: MMP-9, matrix metalloproteinase-9; RhoA, Ras homolog gene family member A; UTR, untranslated region.